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KMID : 0380020080230050408
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Korean Journal of Biotechnology and Bioengineering
2008 Volume.23 No. 5 p.408 ~ p.412
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Preparation and Characterization of Rosiglitazone-loaded PLGA Nanoparticles
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Abstract
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The rosiglitazone loaded poly (lactide-co-glycolide) (PLGA) nanoparticles (NPs) were prepared by the emulsion-evaporation method and optimized for particle size and entrapment efficiency. The optimized particles were 140-180 nm in size with narrow size distribution and 80% entrapment efficiency at 1% w/w initial drug loading when prepared with 1-3% w/v of PVA as a surfactant. These particulate carriers exhibited controlled in vitro release of rosiglitazone for 36 hrs at a nearly constant rate after 4 hrs release. In conclusion, these results indicate that PLGA NPs have greater potential for oral delivery of rosiglitazone.
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KEYWORD
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rosiglitazone, PLGA, nanoparticles, drug delivery
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